Increases Lipoprotein Lipase Activity with Resulting Elevation of High Density Lipoprotein Cholesterol, and Long-term Administra tion Inhibits Atherogenesis in the Coronary Arteries of Rats
نویسندگان
چکیده
Kazuhiko Tsutsumi, et al., “The Novel Compound NO-1886 Increases Lipoprotein Lipase Activity with Resulting Elevation of High Density Lipoprotein Cholesterol, and Long-term Administra tion Inhibits Atherogenesis in the Coronary Arteries of Rats with Experimental Atherosclerosis”. J. Clin. Invest., vol. 92, pp. 411-417 (Jul 1993). Kazuhiko Tsutsumi, et al., “Suppression of Hyperlipidemia-Associ ated Cataracts in Diabetic Rats with the Lipoprotein Lipase Activator NO-1886, Biol. Pharm. Bull., vol. 19, No. 12, pp. 1570-1573 (1996). Ikuo Kawamura, et al., “Effect of Lipoprotein Lipase Activators Bezafibrate and NO-1885, on B16 Melanoma-Induced Cachexia in Mice'. Anticancer Research, vol. 19, pp. 4099-4104 (1999). Kaori Nakayama, et al., “Effect of the Lipoprotein Lipase Activator NO-1866 on Adriamycin-Induced Nephrotic Syndrome in Rats'. Metabolism, vol. 49, No. 5, pp. 588-593 (May 2000). Kazuhiko Tsutsumi, et al., "Correction of Hypertriglyceridemia with Low High-Density Lipoprotein Cholesterol by the Novel Compound NO-1886, a Lipoprotein Lipase-Promoting Agent, in STZ-Induced Diabetic Rats', Diabetes, vol. 44, pp. 414-417 (Apr. 1995). M. Kusunoki, et al., “The lipoprotein lipase activator, NO-1886, Suppresses fat accumulation and insulin resistance in rats fed a high fat diet”. Diabetologia, vol.43, pp. 875-880 (2000). Supplementary European Search Report dated Aug. 16, 2012 in EP 10 73 8531.
منابع مشابه
The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis.
We have discovered a novel compound, NO-1886, which possesses a powerful lipoprotein lipase (LPL) activity-increasing action. Administration of NO-1886 increased LPL activity in the postheparin plasma, adipose tissue, and myocardium of rats, and produced a reduction in plasma triglyceride levels with concomitant elevation of HDL cholesterol levels. Administration of NO-1886 increased LPL enzyme...
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Lipoprotein lipase (LPL) is a rate-limiting enzyme that hydrolyzes circulating triglyceride-rich lipoprotein such as very low density lipoproteins and chylomicrons. A decrease in LPL activity is associated with an increase in plasma triglycerides (TG) and decrease in high density lipoprotein (HDL) cholesterol. The increase in plasma TG and decrease in HDL cholesterol are risk factors of coronar...
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